Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 1/20 | 0.45 |
| ▸ | SPR | P35270 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691732 | 0.87 | KDM4E (0.43) | ALDH1A1MAPTHSD11B1MAPK11MAPK14 | |
| SCHEMBL4690864 | 0.84 | RIPK2 (0.40) | EIF4A3SPRSLC9A1SLC9A2MAPK11 | |
| SCHEMBL4694094 | 0.83 | CHRNB2 (0.44) | ALDH1A1HPGDCCR5 | |
| SCHEMBL4693316 | 0.82 | EIF4A3 (0.39) | EIF4A3MAPK14PTGS2HCRTR1HCRTR2 | |
| SCHEMBL4691531 | 0.81 | HCRTR1 (0.41) | CCR5HCRTR1HCRTR2 | |
| SCHEMBL4690551 | 0.80 | MAPK14 (0.41) | ALDH1A1MAPK11MAPK14PTGS2HPGD | |
| SCHEMBL4694116 | 0.78 | HCRTR2 (0.38) | CCR5HCRTR1HCRTR2 | |
| SCHEMBL4693574 | 0.78 | CCR5 (0.40) | ALDH1A1CCR5HCRTR1HCRTR2 | |
| SCHEMBL4691933 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTHSD11B1MAPK11MAPK14 | |
| SCHEMBL4690347 | 0.77 | HCRTR2 (0.42) | CCR5HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |