Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694319 | 0.81 | CRHR1 (0.37) | TLR8CRHR1NPC1PDE10A | |
| SCHEMBL3965286 | 0.80 | CRHR1 (0.52) | CYP2A6CRHR1SMPD3 | |
| SCHEMBL4694546 | 0.77 | CRHR1 (0.39) | TLR8CRHR1 | |
| SCHEMBL4787114 | 0.77 | TLR8 (0.38) | TLR8CRHR1SMPD3 | |
| SCHEMBL4690722 | 0.75 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL10469274 | 0.70 | CYP2A6 (0.59) | CYP2A6TLR8NPC1 | |
| SCHEMBL4693232 | 0.69 | ATP4A (0.35) | TLR8SMPD3 | |
| SCHEMBL3935197 | 0.69 | SMPD3 (0.35) | CRHR1SMPD3 | |
| SCHEMBL4689722 | 0.69 | CRHR1 (0.32) | TLR8CRHR1 | |
| SCHEMBL4694246 | 0.69 | CRHR1 (0.32) | TLR8CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |