SCHEMBL4694329

SCHEMBL4694329

Cc1ccc(NCC(O)CN2CC3CN(C(=O)c4ccccc4C#N)CC3C2)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.47
HCRTR2 O43614 2/20 0.47
MAPT P10636 4/20 0.37
ALDH1A1 P00352 4/20 0.37
GAA P10253 2/20 0.37
AGTR1 P30556 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HRH1 P35367 1/20 0.35
CCR3 P51677 1/20 0.35
HTT P42858 2/20 0.35
CCR5 P51681 4/20 0.35
PDE2A O00408 1/20 0.35
CCL5 P13501 1/20 0.35
HSD11B1 P28845 1/20 0.35
CTSS P25774 1/20 0.35
HPGD P15428 1/20 0.35
CYP2D6 P10635 2/20 0.34
OPRK1 P41145 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
PGR P06401 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4694325 0.87 HCRTR1 (0.48) HCRTR1HCRTR2MAPTALDH1A1GAA
SCHEMBL4693911 0.84 HCRTR1 (0.48) HCRTR1HCRTR2MAPTALDH1A1GAA
SCHEMBL3283296 0.83 CCR5 (0.48) HCRTR1HCRTR2MAPTALDH1A1GAA
SCHEMBL4697502 0.82 P2RX7 (0.48)
SCHEMBL4693905 0.81 HCRTR1 (0.48) HCRTR1HCRTR2MAPTALDH1A1GAA
SCHEMBL4694037 0.79 MALT1 (0.42) HCRTR1HCRTR2MAPTALDH1A1GAA
SCHEMBL4690649 0.78 CCR5 (0.47) MAPTHTTCCR5CCL5
SCHEMBL4692314 0.77 LMNA (0.45) HCRTR1HCRTR2MAPTSMN1; SMN2HTT
SCHEMBL13359815 0.74 CCR5 (0.50) HCRTR1HCRTR2CCR5
SCHEMBL3283988 0.74 CCR5 (0.48) HCRTR1HCRTR2MAPTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed