Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694034 | 0.87 | MALT1 (0.46) | MALT1MAPTHTTTP53CYP11B1 | |
| SCHEMBL3283296 | 0.84 | CCR5 (0.48) | MAPTHTTHCRTR1HCRTR2LMNA | |
| SCHEMBL4690649 | 0.84 | CCR5 (0.47) | MAPTHTTCCR5 | |
| SCHEMBL4689933 | 0.84 | MALT1 (0.43) | MALT1MAPTHTTTP53CYP11B1 | |
| SCHEMBL4689928 | 0.80 | MALT1 (0.47) | MALT1MAPTTP53KMT2ALMNA | |
| SCHEMBL4694329 | 0.79 | HCRTR1 (0.47) | MAPTHTTHCRTR1HCRTR2CCR5 | |
| SCHEMBL4693294 | 0.79 | PDE10A (0.42) | MALT1MAPTHTTTP53HCRTR1 | |
| SCHEMBL4692314 | 0.78 | LMNA (0.45) | MAPTHTTHCRTR1HCRTR2MEN1 | |
| SCHEMBL4697502 | 0.78 | P2RX7 (0.48) | — | |
| SCHEMBL13359815 | 0.76 | CCR5 (0.50) | HCRTR1HCRTR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |