Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935196 | 0.95 | HPGD (0.44) | PREPCHRM2CHRM1CHRM3HPGD | |
| SCHEMBL17128208 | 0.91 | NR1H2 (0.48) | PREPCHRM2CHRM1CHRM3HPGD | |
| SCHEMBL20587386 | 0.84 | PREP (0.48) | PREPCHRM2CHRM1CHRM3HPGD | |
| SCHEMBL31209483 | 0.78 | HPGD (0.48) | PREPCHRM2CHRM1CHRM3HPGD | |
| SCHEMBL5041372 | 0.78 | HPGD (0.48) | PREPCHRM2CHRM1CHRM3HPGD | |
| SCHEMBL16707781 | 0.77 | JAK2 (0.53) | JAK2JAK1USP30SMN1; SMN2GPR119 | |
| SCHEMBL31208756 | 0.75 | HPGD (0.46) | PREPCHRM2CHRM1CHRM3HPGD | |
| SCHEMBL31209310 | 0.75 | ACHE (0.44) | HPGDMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL31209177 | 0.75 | ACHE (0.44) | HPGDMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL14196264 | 0.75 | HPGD (0.51) | PREPHPGDMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358243-B2 | Diazabicyclonane and-decane derivatives and their use as opioid receptor ligands | NEUROSEARCH A/S (DK) | 2008-04-15 | — | — | US | disclosed |
| EP-1527075-B1 | DIAZABICYCLONONANE AND -DECANE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH AS (DK) | 2008-03-26 | — | — | EP | disclosed |
| US-20050239773-A1 | Diazabicyclonane and-decane derivatives and their use as opioid receptor ligands | ANIONA APS (DK) | 2005-10-27 | — | — | US | disclosed |
| EP-1527075-A1 | DIAZABICYCLONONANE AND -DECANE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004011468-A1 | DIAZABICYCLONONANE AND -DECANE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2004-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239773-A1 | Diazabicyclonane and-decane derivatives and their use as opioid receptor ligands | OPRM1, OPRD1, OPRK1 | PREP 3123/4885CHRM2 391/4885CHRM1 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.