Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 5/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238361 | 0.93 | HPGD (0.43) | PLA2G10RAB9ATDP1L3MBTL1HPGD | |
| SCHEMBL5232788 | 0.88 | CHRNB2 (0.44) | PLA2G10L3MBTL1PLA2G2A | |
| SCHEMBL5233538 | 0.88 | ALDH1A1 (0.47) | ALDH1A1NPSR1PLA2G10HCRTR1HCRTR2 | |
| SCHEMBL4692413 | 0.86 | HCRTR1 (0.53) | PLA2G10HCRTR1HCRTR2 | |
| SCHEMBL5231026 | 0.85 | HPGD (0.42) | ALDH1A1PLA2G10HPGDPLA2G2A | |
| SCHEMBL5237823 | 0.85 | SLC6A7 (0.36) | PLA2G10HCRTR1HCRTR2HPGDPLA2G2A | |
| SCHEMBL5237460 | 0.84 | PLA2G10 (0.39) | ALDH1A1PLA2G10HPGDHTR7PLA2G2A | |
| SCHEMBL4694475 | 0.84 | SMN1; SMN2 (0.47) | ALDH1A1HPGD | |
| SCHEMBL5237286 | 0.84 | LMNA (0.43) | ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL5235769 | 0.83 | CHRNA4 (0.47) | ALDH1A1PLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |