Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18287146 | 0.89 | TRPM8 (0.58) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL18287162 | 0.87 | TRPM8 (0.53) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL3228965 | 0.85 | EPHX1 (0.58) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL15016267 | 0.85 | EPHX1 (0.58) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL930592 | 0.85 | EPHX1 (0.58) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL15016269 | 0.85 | EPHX1 (0.58) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL29177116 | 0.85 | EPHX1 (0.58) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL120087 | 0.85 | EPHX1 (0.58) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL18287149 | 0.78 | TRPM8 (0.56) | TRPM8EPHX1TRPV1TRPA1 | |
| SCHEMBL28841473 | 0.78 | TRPM8 (0.52) | TRPM8EPHX1TRPV1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893072-B2 | Cool-genic compounds as anticarcinogenic agents promoting apoptosis and inhibit angiogenesis; antiproliferative agents | GENENTECH, INC. (US) | 2011-02-22 | — | — | US | claimed |
| US-4150052-A | PHYSIOLOGICAL COOLING EFFECT ON SKIN | WILKINSON SWORD LIMITED (GB) | 1979-04-17 | — | — | US | claimed |
| US-4060091-A | N-SUBSTITUTED P-MENTHANE CARBOXAMID | WILKINSON SWORD LIMITED (EN) | 1977-11-29 | — | — | US | claimed |
| EP-4268814-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | Universidad Miguel Hernández De Elche (ES) | 2023-11-01 | — | — | EP | disclosed |
| US-10028920-B2 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2018-07-24 | — | — | US | disclosed |
| US-9901549-B2 | Method for treating vaginal dryness by administering transient receptor potential cation channel subfamily M member 8 (TRPM8) receptor agonists | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2018-02-27 | — | — | US | disclosed |
| EP-1656144-B2 | TRP-P8 ACTIVE COMPOUNDS AND THERAPEUTIC TREATMENT METHODS | GENENTECH INC (US) | 2017-12-20 | — | — | EP | disclosed |
| US-20170071875-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C. (ES) | 2017-03-16 | — | — | US | disclosed |
| US-20170049728-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C. (ES) | 2017-02-23 | — | — | US | disclosed |
| US-9433679-B2 | Use of TRMP8 for treating opthalmic diseases or conditions involving tearing | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2016-09-06 | — | — | US | disclosed |
| US-20150313854-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2015-11-05 | — | — | US | disclosed |
| WO-2012032209-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2012-03-15 | — | — | WO | disclosed |
| US-20120045448-A1 | TRP-P8 ACTIVE COMPOUNDS AND THERAPEUTIC TREATMENT METHODS | GENENTECH, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| US-7893072-B2 | Cool-genic compounds as anticarcinogenic agents promoting apoptosis and inhibit angiogenesis; antiproliferative agents | GENENTECH, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893072-B2 | Cool-genic compounds as anticarcinogenic agents promoting apoptosis and inhibit angiogenesis; antiproliferative agents | GENENTECH, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-4226988-A | SKIN COOLANTS | WILKINSON SWORD LIMITED (GB) | 1980-10-07 | — | — | US | disclosed |
| US-4193936-A | N-substituted paramenthane carboxamides | WILKINSON SWORD LIMITED (GB) | 1980-03-18 | — | — | US | disclosed |
| US-4178459-A | N-Substituted paramenthane carboxamides | WILKINSON SWORD LIMITED (GB) | 1979-12-11 | — | — | US | disclosed |
| US-4150052-A | PHYSIOLOGICAL COOLING EFFECT ON SKIN | WILKINSON SWORD LIMITED (GB) | 1979-04-17 | — | — | US | disclosed |
| US-4136163-A | P-MENTHANE CARBOXAMIDES HAVING A PHYSIOLOGICAL COOLING EFFECT | WILKINSON SWORD LIMITED (GB) | 1979-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10028920-B2 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 | TRPM8, TRPM5, TRPM7 | TRPM8 1/4885EPHX1 1020/4885TRPV1 8/4885 |
| US-20170049728-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885EPHX1 1393/4885TRPV1 10/4885 |
| US-20150313854-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885EPHX1 1393/4885TRPV1 10/4885 |
| US-20120045448-A1 | TRP-P8 ACTIVE COMPOUNDS AND THERAPEUTIC TREATMENT METHODS | TSG101, TP53, BAX | TRPM8 28/4885EPHX1 1033/4885TRPV1 14/4885 |
| US-20170071875-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885EPHX1 1393/4885TRPV1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.