Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.58 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15016269 | 1.00 | EPHX1 (0.58) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL29177116 | 1.00 | EPHX1 (0.58) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL15016267 | 1.00 | EPHX1 (0.58) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL120087 | 1.00 | EPHX1 (0.58) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL3228965 | 1.00 | EPHX1 (0.58) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL14072907 | 0.88 | EPHX1 (0.44) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL14072905 | 0.88 | EPHX1 (0.44) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL469472 | 0.85 | TRPM8 (0.54) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL18287146 | 0.85 | TRPM8 (0.58) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL18287162 | 0.84 | TRPM8 (0.53) | EPHX1TRPM8TRPA1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110869365-B | Cooling composition | 弗门尼舍有限公司 | 2024-03-29 | — | — | CN | claimed |
| EP-2276356-B1 | WARMING SENSATE COMPOSITION | FIRMENICH & CIE (CH) | 2013-06-19 | — | — | EP | claimed |
| US-20110015227-A1 | WARMING SENSATE COMPOSITION | FIRMENICH SA (CH) | 2011-01-20 | — | — | US | claimed |
| US-20080000614-A1 | HOT FLAVOR AND SKIN SENSATION COMPOSITION | FIRMENICH SA (CH) | 2008-01-03 | — | — | US | claimed |
| US-20240225915-A1 | COMPOSITIONS FOR FIGHTING MALODORS | SYMRISE AG (DE) | 2024-07-11 | — | — | US | disclosed |
| US-11744787-B2 | Menthol-containing aroma preparations | SYMRISE AG (DE) | 2023-09-05 | — | — | US | disclosed |
| US-11696884-B2 | Compositions comprising menthol compounds as smoothing agents | SYMRISE AG (DE) | 2023-07-11 | — | — | US | disclosed |
| US-20180055069-A1 | PREPARATIONS | SYMRISE AG (DE) | 2018-03-01 | — | — | US | disclosed |
| US-20180049449-A1 | PREPARATIONS | SYMRISE AG (DE) | 2018-02-22 | — | — | US | disclosed |
| US-20180042832-A1 | COMPOSITIONS COMPRISING MENTHOL COMPOUNDS AS SMOOTHING AGENTS | SYMRISE AG (DE) | 2018-02-15 | — | — | US | disclosed |
| US-20170368521-A1 | METHOD FOR STORING COOLING AGENTS | SYMRISE AG (DE) | 2017-12-28 | — | — | US | disclosed |
| US-9743685-B2 | Mixtures having improved cooling effect | SYMRISE AG (DE) | 2017-08-29 | — | — | US | disclosed |
| US-20140335224-A1 | COOLING COMPOSITION | SYMRISE AG (DE) | 2014-11-13 | — | — | US | disclosed |
| US-20130195773-A1 | COMPOSITIONS | SYMRISE AG (DE) | 2013-08-01 | — | — | US | disclosed |
| US-20130195773-A1 | COMPOSITIONS | SYMRISE AG (DE) | 2013-08-01 | — | — | US | disclosed |
| US-7482378-B2 | Physiological cooling compositions | MILLENIUM SPECIALTY CHEMICALS, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| WO-2008138162-A1 | COMPOSITIONS AND THEIR USE | GIVAUDAN SA (CH) | 2008-11-20 | — | — | WO | disclosed |
| EP-1874132-A1 | HOT FLAVOUR AND SKIN SENSATION COMPOSITION | FIRMENICH SA (CH) | 2008-01-09 | — | — | EP | disclosed |
| US-20080000614-A1 | HOT FLAVOR AND SKIN SENSATION COMPOSITION | FIRMENICH SA (CH) | 2008-01-03 | — | — | US | disclosed |
| WO-2006109241-A1 | HOT FLAVOUR AND SKIN SENSATION COMPOSITION | FIRMENICH SA (CH) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11696884-B2 | Compositions comprising menthol compounds as smoothing agents | SMURF1, SMURF2, S1PR2 | EPHX1 2359/4885TRPM8 32/4885TRPA1 23/4885 |
| US-20180042832-A1 | COMPOSITIONS COMPRISING MENTHOL COMPOUNDS AS SMOOTHING AGENTS | SMURF1, SMURF2, S1PR2 | EPHX1 2359/4885TRPM8 32/4885TRPA1 23/4885 |
| US-11744787-B2 | Menthol-containing aroma preparations | CHRM1, MSMO1, NR1H3 | EPHX1 447/4885TRPM8 108/4885TRPA1 63/4885 |
| US-20110015227-A1 | WARMING SENSATE COMPOSITION | TAS1R3, TAS2R30, TAS2R50 | EPHX1 3988/4885TRPM8 76/4885TRPA1 28/4885 |
| US-20180049449-A1 | PREPARATIONS | CRAT, ACAT2, TAS2R50 | EPHX1 1451/4885TRPM8 101/4885TRPA1 188/4885 |
| US-20180055069-A1 | PREPARATIONS | CRAT, ACAT2, TAS2R50 | EPHX1 1451/4885TRPM8 101/4885TRPA1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.