Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CPS1 | P31327 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692712 | 0.93 | HCRTR1 (0.43) | HCRTR1HCRTR2P2RX7ALDH1A1MGLL | |
| SCHEMBL4695935 | 0.93 | HCRTR2 (0.47) | HCRTR1HCRTR2P2RX7ALDH1A1HPGD | |
| SCHEMBL4693718 | 0.91 | TSHR (0.38) | HCRTR1HCRTR2HPGDMGLLTNF | |
| SCHEMBL4691904 | 0.90 | HCRTR1 (0.46) | HCRTR1HCRTR2LMNAUSP2ALDH1A1 | |
| SCHEMBL4690738 | 0.90 | HCRTR1 (0.46) | HCRTR1HCRTR2LMNAP2RX7ALDH1A1 | |
| SCHEMBL4694969 | 0.89 | HCRTR1 (0.38) | HCRTR1HCRTR2USP2P2RX7HPGD | |
| SCHEMBL4694083 | 0.88 | TSHR (0.40) | HCRTR1HCRTR2ALDH1A1HPGDTNF | |
| SCHEMBL4692944 | 0.87 | HCRTR1 (0.41) | HCRTR1HCRTR2P2RX7ALDH1A1CPS1 | |
| SCHEMBL4692703 | 0.87 | HCRTR1 (0.48) | HCRTR1HCRTR2P2RX7ALDH1A1MGLL | |
| SCHEMBL4694165 | 0.86 | HCRTR1 (0.48) | HCRTR1HCRTR2P2RX7HPGDTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |