SCHEMBL4695341

SCHEMBL4695341

CN(C)c1ccc(/C=C/C(=O)c2ccc(Cl)cc2)c(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 4/20 0.55
MAPT P10636 8/20 0.52
LMNA P02545 4/20 0.52
HPGD P15428 3/20 0.52
CYP1A2 P05177 2/20 0.51
CYP2C19 P33261 2/20 0.51
ALOX12 P18054 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.50
NPC1 O15118 3/20 0.50
RAB9A P51151 2/20 0.50
ALDH1A1 P00352 2/20 0.50
MAPK1 P28482 1/20 0.50
CASP3 P42574 1/20 0.50
KMT2A Q03164 1/20 0.50
CYP1B1 Q16678 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
POLB P06746 1/20 0.50
KDM4E B2RXH2 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4695343 1.00 BACE1 (0.55) BACE1MAPTLMNAHPGDCYP1A2
SCHEMBL1225557 0.84 LMNA (0.65) MAPTLMNAHPGDCYP1A2CYP2C19
SCHEMBL1225556 0.84 LMNA (0.65) MAPTLMNAHPGDCYP1A2CYP2C19
Bromide SCHEMBL11834524 0.82 LMNA (0.63) MAPTLMNAHPGDCYP1A2CYP2C19
Bromide SCHEMBL11834530 0.82 LMNA (0.63) MAPTLMNAHPGDCYP1A2CYP2C19
SCHEMBL4280610 0.81 BACE1 (0.61) BACE1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL4280612 0.81 BACE1 (0.61) BACE1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL3687525 0.80 MAPT (0.50) BACE1MAPTLMNAHPGDCYP1A2
SCHEMBL4692915 0.80 CRHBP (0.75) MAPTSMN1; SMN2NPC1RAB9AMAPK1
SCHEMBL4692916 0.80 CRHBP (0.75) MAPTSMN1; SMN2NPC1RAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8754179-B2 Light activated shape memory co-polymers CORNERSTONE RESEARCH GROUP, INC. (US) 2014-06-17 US disclosed
US-20080021166-A1 Light Activated Shape Memory Co-Polymers GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE 2008-01-24 US disclosed
EP-1799771-A2 LIGHT ACTIVATED SHAPE MEMORY CO-POLYMERS CORNERSTONE RESEARCH GROUP, INC. (US) 2007-06-27 EP disclosed
WO-2007001407-A2 LIGHT ACTIVATED SHAPE MEMORY CO-POLYMERS CORNERSTONE RESEARCH GROUP, INC. (US) 2007-01-04 WO disclosed