Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695787 | 0.83 | TP53 (0.39) | THRBLMNATP53MAPTMALT1 | |
| SCHEMBL4695896 | 0.80 | POLB (0.46) | THRBTP53MAPTNPC1RAB9A | |
| SCHEMBL4694793 | 0.79 | MAPT (0.43) | THRBLMNATP53MAPTNPC1 | |
| SCHEMBL3282221 | 0.78 | CCR5 (0.51) | LMNATP53MAPTALDH1A1GLA | |
| SCHEMBL3286924 | 0.77 | TP53 (0.53) | LMNATP53MAPTALDH1A1CYP2C9 | |
| SCHEMBL4747293 | 0.75 | CCR5 (0.36) | RAB9A | |
| SCHEMBL4693617 | 0.72 | CCR5 (0.51) | LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL3285287 | 0.72 | TP53 (0.43) | LMNATP53MAPTRAB9AALDH1A1 | |
| SCHEMBL3283571 | 0.71 | CCR5 (0.44) | THRBLMNATP53MAPTALDH1A1 | |
| SCHEMBL4695429 | 0.70 | CCR5 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |