Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695245 | 0.81 | MAPT (0.48) | MAPTTHRBTP53LMNAKMT2A | |
| SCHEMBL4696289 | 0.79 | THRB (0.38) | MAPTTHRBTP53LMNANPC1 | |
| SCHEMBL4695896 | 0.79 | POLB (0.46) | MAPTTHRBTP53KMT2AMEN1 | |
| SCHEMBL4695787 | 0.77 | TP53 (0.39) | MAPTTHRBTP53LMNAKMT2A | |
| SCHEMBL3286924 | 0.75 | TP53 (0.53) | MAPTTP53LMNAKMT2AMEN1 | |
| SCHEMBL4695249 | 0.68 | RECQL (0.48) | MAPTTP53LMNAKMT2AMEN1 | |
| SCHEMBL3281859 | 0.67 | CCR5 (0.52) | TP53LMNAKMT2AMEN1TSHR | |
| SCHEMBL4692884 | 0.66 | LMNA (0.48) | MAPTTHRBTP53LMNAKMT2A | |
| SCHEMBL4693095 | 0.65 | TP53 (0.45) | MAPTTP53LMNAKMT2AMEN1 | |
| SCHEMBL4692723 | 0.65 | CHRNB2 (0.47) | MAPTTP53LMNAKMT2AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |