Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696289 | 0.80 | THRB (0.38) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL4694793 | 0.79 | MAPT (0.43) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL4695787 | 0.78 | TP53 (0.39) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4693609 | 0.78 | SMN1; SMN2 (0.52) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3286924 | 0.75 | TP53 (0.53) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4689516 | 0.70 | MAPT (0.61) | POLBKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4690926 | 0.69 | MAPT (0.54) | KMT2AMAPTSMN1; SMN2ALDH1A1DRD2 | |
| SCHEMBL4692326 | 0.68 | CCR5 (0.51) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4693892 | 0.67 | HCRTR1 (0.47) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL4691831 | 0.67 | MAPT (0.51) | POLBMEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |