Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16606256 | 0.82 | CSNK2A1 (0.49) | CSNK2A1TRPA1PTGS2CYP1A2CYP2A6 | |
| SCHEMBL17805387 | 0.79 | PKM (0.43) | CSNK2A1TRPA1PTGS2CYP1A2CYP2A6 | |
| SCHEMBL19578912 | 0.79 | PTGS2 (0.52) | TRPA1PTGS2CYP1A2MAPK1LMNA | |
| SCHEMBL14190879 | 0.78 | CA2 (0.52) | CSNK2A1PTGS2CYP1A2MAPK1LMNA | |
| SCHEMBL14948760 | 0.78 | CSNK2A1 (0.53) | CSNK2A1TRPA1RXRAPTGS2CYP1A2 | |
| SCHEMBL14468495 | 0.78 | CSNK2A1 (0.41) | CSNK2A1TRPA1PTGS2CYP1A2CYP2A6 | |
| SCHEMBL8372213 | 0.78 | CA2 (0.52) | CSNK2A1PTGS2CYP1A2LMNAALDH1A1 | |
| SCHEMBL8180613 | 0.78 | CSNK2A1 (0.41) | CSNK2A1KCNH2TMEM97SIGMAR1 | |
| SCHEMBL12327573 | 0.78 | TRPA1 (0.53) | TRPA1MAPK1LMNATSHRALOX15 | |
| SCHEMBL28805392 | 0.76 | CSNK2A1 (0.45) | CSNK2A1TRPA1PTGS2CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| CN-1604778-A | Cis-imidazolines as MDM2 inhibitors | HOFFMANN LA ROCHE (CH) | 2005-04-06 | — | — | CN | disclosed |
| EP-1463501-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6617346-B1 | Inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity | HOFFMANN-LA ROCHE INC. | 2003-09-09 | — | — | US | disclosed |
| WO-2003051360-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |