Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.73 |
| ▸ | HTR3A | P46098 | 4/20 | 0.66 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909783 | 0.93 | KCNH2 (0.63) | KCNH2HTR3ACHRNA7 | |
| SCHEMBL5326653 | 0.93 | KCNH2 (0.63) | KCNH2HTR3ACHRNA7 | |
| SCHEMBL5326649 | 0.93 | KCNH2 (0.63) | KCNH2HTR3ACHRNA7 | |
| SCHEMBL6139385 | 0.85 | KCNH2 (1.00) | KCNH2HTR3ACHRNA7 | |
| SCHEMBL6139396 | 0.85 | KCNH2 (0.73) | KCNH2HTR3ACHRNA7 | |
| Bromide SCHEMBL6139238 | 0.84 | KCNH2 (0.97) | KCNH2HTR3ACHRNA7 | |
| Bromide SCHEMBL5674269 | 0.84 | KCNH2 (0.72) | KCNH2HTR3ACHRNA7 | |
| SCHEMBL4698821 | 0.81 | KCNH2 (0.67) | KCNH2HTR3ACHRNA7 | |
| SCHEMBL4699143 | 0.80 | HTR3A (1.00) | KCNH2HTR3ACHRNA7 | |
| SCHEMBL5246818 | 0.79 | KCNH2 (0.65) | KCNH2HTR3ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439236-B2 | Pharmaceutical composition for the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-21 | — | — | US | claimed |
| EP-1219622-B1 | Pharmaceutical compositions for CNS and other disorders | PFIZER PROD INC (US) | 2008-06-18 | — | — | EP | claimed |
| US-20070099904-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CNS AND OTHER DISORDERS | PFIZER INC | 2007-05-03 | — | — | US | claimed |
| US-6809094-B2 | N-FUSED HETERCYCLO-1,4- OR -1,5- DIAZABICYCLO DERIVATIVES; NICOTINIC RECEPTOR AGONISTS; CENTRAL NERVOUS SYSTEM (CNS) | PFIZER INC | 2004-10-26 | — | — | US | claimed |
| US-7439236-B2 | Pharmaceutical composition for the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-21 | — | — | US | disclosed |
| EP-1219622-B1 | Pharmaceutical compositions for CNS and other disorders | PFIZER PROD INC (US) | 2008-06-18 | — | — | EP | disclosed |
| US-20070099904-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CNS AND OTHER DISORDERS | PFIZER INC | 2007-05-03 | — | — | US | disclosed |
| US-7119087-B2 | 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2006-10-10 | — | — | US | disclosed |
| US-20060142349-A1 | Methods of modulating the activities of alpha-7 nicotinic acetylcholine receptor | PFIZER INC | 2006-06-29 | — | — | US | disclosed |
| WO-2006051413-A1 | AZABENOXAZOLES FOR THE TREATMENT OF CNS DISORDERS | PFIZER INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| US-20050176720-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | PFIZER INC | 2005-08-11 | — | — | US | disclosed |
| US-6881734-B2 | Pharmaceutical composition for the treatment of CNS and other disorders | PFIZER INC. (US) | 2005-04-19 | — | — | US | disclosed |
| US-20050004128-A1 | 4-(Oxazolopyridin-2-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2005-01-06 | — | — | US | disclosed |
| US-6809094-B2 | N-FUSED HETERCYCLO-1,4- OR -1,5- DIAZABICYCLO DERIVATIVES; NICOTINIC RECEPTOR AGONISTS; CENTRAL NERVOUS SYSTEM (CNS) | PFIZER INC | 2004-10-26 | — | — | US | disclosed |
| US-20040204416-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | PFIZER INC | 2004-10-14 | — | — | US | disclosed |
| US-20030119837-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | PFIZER INC. | 2003-06-26 | — | — | US | disclosed |
| US-20020086871-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | O'NEILL BRIAN THOMAS (US) | 2002-07-04 | — | — | US | disclosed |
| EP-1219622-A2 | Pharmaceutical compositions for CNS and other disorders | Pfizer Products Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176720-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | CHRNA7, CHRNA10, CHRNA5 | KCNH2 959/4885HTR3A 144/4885CHRNA7 1/4885 |
| US-20030119837-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | CHRNA7, CHRNA5, CHRNA10 | KCNH2 1560/4885HTR3A 147/4885CHRNA7 1/4885 |
| US-20050004128-A1 | 4-(Oxazolopyridin-2-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof | ARG2, OXA1L, GOT2 | KCNH2 489/4885HTR3A 1189/4885CHRNA7 1734/4885 |
| US-20020086871-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | CHRNA7, CHRNA5, CHRNA10 | KCNH2 1560/4885HTR3A 147/4885CHRNA7 1/4885 |
| US-20070099904-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CNS AND OTHER DISORDERS | C1QBP, BCHE, BDNF | KCNH2 1166/4885HTR3A 462/4885CHRNA7 75/4885 |
| US-20060142349-A1 | Methods of modulating the activities of alpha-7 nicotinic acetylcholine receptor | CHRNA7, CHRNA5, CHRNA4 | KCNH2 451/4885HTR3A 238/4885CHRNA7 1/4885 |
| US-20040204416-A1 | Pharmaceutical composition for the treatment of CNS and other disorders | CHRNA7, CHRNA5, CHRNA10 | KCNH2 1560/4885HTR3A 147/4885CHRNA7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.