Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL560892 | 0.95 | MEN1 (0.50) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL29502259 | 0.93 | MEN1 (0.48) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Bromide SCHEMBL20984135 | 0.93 | MEN1 (0.48) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL670341 | 0.93 | MEN1 (0.48) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Phosphoric Acid SCHEMBL20984142 | 0.84 | MEN1 (0.50) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL20984279 | 0.84 | MEN1 (0.55) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Sulfuric Acid SCHEMBL20984124 | 0.84 | MEN1 (0.50) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL21357403 | 0.81 | ALDH1A1 (0.50) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Nitric Acid SCHEMBL20984111 | 0.81 | MEN1 (0.47) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL6893 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963275-A2 | P2X7 RECEPTOR ANTAGONISTS AND USES THEREOF | Abbott Laboratories (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20070259920-A1 | P2X7, receptor antagonists and uses thereof | ABBOTT LABORATORIES | 2007-11-08 | — | — | US | disclosed |
| WO-2007056091-A2 | 2-PHENYL-2H-PYRAZ0LE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259920-A1 | P2X7, receptor antagonists and uses thereof | P2RX7, P2RX1, P2RX3 | MEN1 3501/4885KMT2A 4301/4885LMNA 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.