Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.60 |
| ▸ | DRD3 | P35462 | 11/20 | 0.60 |
| ▸ | DRD2 | P14416 | 6/20 | 0.60 |
| ▸ | PKM | P14618 | 5/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702240 | 0.89 | HTR6 (0.61) | HTR6DRD3DRD2PKMJAK2 | |
| SCHEMBL4699249 | 0.81 | HTR6 (0.60) | HTR6DRD3DRD2PKMJAK2 | |
| Hydrochloric Acid SCHEMBL4700533 | 0.80 | HTR6 (0.59) | HTR6DRD3DRD2PKMJAK2 | |
| SCHEMBL9903167 | 0.79 | HTR6 (0.58) | HTR6DRD3DRD2ALDH1A1HTR1A | |
| SCHEMBL9901916 | 0.76 | HTR3A (0.51) | HTR6DRD2ALDH1A1HTR2AHTR2C | |
| SCHEMBL9903412 | 0.75 | HTR6 (0.60) | HTR6DRD2ALDH1A1HTR2AHTR2C | |
| SCHEMBL9903357 | 0.74 | HTR6 (0.59) | HTR6DRD2ALDH1A1HTR2AHTR2C | |
| SCHEMBL9902699 | 0.73 | HTR3A (0.48) | HTR6DRD2ALDH1A1HTR2CHTR7 | |
| SCHEMBL9903510 | 0.73 | HTR6 (0.60) | HTR6DRD2HTR2CHTR7HTR3A | |
| SCHEMBL9903853 | 0.73 | HTR6 (0.60) | HTR6DRD2HTR2AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660483-B1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-12-24 | — | — | EP | claimed |