Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.61 |
| ▸ | DRD3 | P35462 | 6/20 | 0.61 |
| ▸ | PKM | P14618 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699254 | 0.89 | HTR6 (0.60) | HTR6DRD3PKMJAK2ALDH1A1 | |
| SCHEMBL4702019 | 0.82 | HTR6 (0.67) | HTR6DRD3PKMJAK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4697947 | 0.81 | HTR6 (0.66) | HTR6DRD3PKMJAK2ALDH1A1 | |
| SCHEMBL4690981 | 0.79 | HTR6 (0.61) | HTR6DRD3CHRNB2CHRNA4DRD2 | |
| SCHEMBL4702293 | 0.78 | CHRNB2 (0.50) | HTR6PKMALDH1A1MCOLN3CHRNB2 | |
| SCHEMBL28393673 | 0.76 | HTR6 (1.00) | HTR6DRD3DRD2KMT2AHRH3 | |
| SCHEMBL4703630 | 0.76 | ALDH1A1 (0.47) | HTR6PKMALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL9903634 | 0.74 | HTR6 (0.50) | HTR6CHRNB2CHRNA4DRD2HTR1A | |
| SCHEMBL4757679 | 0.73 | HTR6 (0.56) | HTR6DRD3CHRNB2CHRNA4HRH3 | |
| SCHEMBL9903085 | 0.72 | HTR6 (0.57) | HTR6ALDH1A1CHRNB2CHRNA4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660483-B1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-12-24 | — | — | EP | claimed |