Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 5/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248105 | 0.85 | — | — | |
| SCHEMBL1447305 | 0.71 | HTT (0.38) | MLYCDTP53SMN1; SMN2 | |
| SCHEMBL6629594 | 0.67 | ACHE (0.30) | — | |
| SCHEMBL27713654 | 0.67 | SMN1; SMN2 (0.39) | MLYCDTP53SMN1; SMN2 | |
| SCHEMBL1449077 | 0.66 | HTT (0.37) | SMN1; SMN2 | |
| SCHEMBL27166571 | 0.66 | ALDH1A1 (0.33) | SMN1; SMN2 | |
| SCHEMBL9856716 | 0.65 | MLYCD (0.44) | MLYCDSMN1; SMN2 | |
| SCHEMBL12740542 | 0.63 | SMN1; SMN2 (0.42) | MLYCDSMN1; SMN2 | |
| SCHEMBL1447253 | 0.63 | MLYCD (0.35) | MLYCDTP53SMN1; SMN2 | |
| SCHEMBL4697112 | 0.63 | HTT (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912974-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1828183-A1 | 4- (4- (IMIDAZOL-4-YL) PYRIMIDIN-2-YLAMINO) BENZAMIDES AS CDK INHIBITORS | AstraZeneca AB (SE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007015064-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | WO | disclosed |
| WO-2006064251-A1 | 4- (4- (IMIDAZOL-4-YL) PYRIMIDIN-2-YLAMINO) BENZAMIDES AS CDK INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |