Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698850 | 0.91 | BDKRB2 (0.35) | BDKRB2ROCK2ALDH1A1HTR2CSLC6A3 | |
| SCHEMBL4698936 | 0.89 | BDKRB2 (0.36) | BDKRB2ROCK2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL4698835 | 0.87 | ROCK2 (0.36) | BDKRB2ROCK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4700242 | 0.85 | PDK1 (0.40) | BDKRB2ROCK2KMT2AMEN1 | |
| SCHEMBL4756002 | 0.85 | ALDH1A1 (0.39) | BDKRB2ALDH1A1HTR2CSLC6A3TAS1R3 | |
| SCHEMBL4702892 | 0.85 | BDKRB2 (0.48) | BDKRB2ROCK2ALDH1A1HTR2CSLC6A3 | |
| SCHEMBL4702365 | 0.84 | OPRM1 (0.34) | BDKRB2ROCK2ALDH1A1HTR2CSLC6A3 | |
| SCHEMBL4698590 | 0.83 | BDKRB2 (0.40) | BDKRB2ROCK2ALDH1A1KMT2AOPRD1 | |
| SCHEMBL6387629 | 0.83 | BDKRB2 (0.43) | BDKRB2ALDH1A1HTR2CSLC6A3ENPP2 | |
| SCHEMBL4701332 | 0.81 | GAA (0.40) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458684-B1 | THERAPEUTIC HETEROCYCLES AS BRADYKININ B2 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | claimed |