Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272401 | 0.90 | KIF11 (0.40) | ALDH1A1LMNAMAPTCFTRRXRA | |
| SCHEMBL2529611 | 0.80 | MT-CO2 (0.42) | MAPTNPC1KDM4ERAB9A | |
| SCHEMBL273986 | 0.75 | MEN1 (0.39) | MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL7667615 | 0.74 | LMNA (0.49) | LMNARXRANR1H2NR1H3KIF11 | |
| SCHEMBL977449 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPTNPC1KDM4EGAA | |
| SCHEMBL3410365 | 0.74 | MT-CO2 (0.39) | ALDH1A1LMNAMAPTRAB9ATDP1 | |
| SCHEMBL5339338 | 0.73 | ATM (0.44) | ALDH1A1POLBLMNAMAPTNPC1 | |
| SCHEMBL29850444 | 0.73 | PPARG (0.39) | PPARGPPARAPOLBLMNAMAPT | |
| SCHEMBL15948302 | 0.72 | F2 (0.38) | LMNAMAPTKDM4E | |
| SCHEMBL14740797 | 0.72 | RAB9A (0.41) | ALDH1A1LMNAMAPTRXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971594-A2 | SUBSTITUTED PYRAZALONES | Biogen Idec MA Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007059359-A2 | SUBSTITUTED PYRAZALONES | BIOGEN IDEC MA INC. (US) | 2007-05-24 | — | — | WO | disclosed |