Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702277 | 0.84 | CRHR1 (0.43) | CRHR1HPGDLMNAALDH1A1KDM4E | |
| SCHEMBL4698860 | 0.80 | CRHR1 (0.44) | CRHR1LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4702339 | 0.80 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL4700167 | 0.80 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL4702631 | 0.79 | POLB (0.36) | CRHR1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4701265 | 0.78 | CRHR1 (0.34) | CRHR1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4701270 | 0.76 | CHRM2 (0.39) | CRHR1HPGDLMNAALDH1A1KDM4E | |
| SCHEMBL4701262 | 0.74 | CRHR1 (0.49) | CRHR1MAPTTSHR | |
| SCHEMBL3364667 | 0.71 | CRHR1 (0.40) | CRHR1KDM4EHSD17B10HRH4MAPT | |
| SCHEMBL4697907 | 0.69 | MAPT (0.31) | HPGDLMNAALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |