Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CA9 | Q16790 | 6/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701748 | 0.92 | DHFR (0.38) | DHFRALDH1A1HPGDTSHRPTGS2 | |
| SCHEMBL4699473 | 0.85 | TDP2 (0.45) | DHFRALDH1A1HPGDTSHRDHODH | |
| SCHEMBL4163320 | 0.77 | GRM1 (0.47) | GRM1CA2CA9CA1CA12 | |
| SCHEMBL4164830 | 0.76 | GRM1 (0.67) | GRM1ALDH1A1HPGDTSHR | |
| SCHEMBL4703033 | 0.74 | DHFR (0.39) | DHFRALDH1A1HPGDTSHRTNKS | |
| SCHEMBL5611826 | 0.73 | DHFR (0.49) | DHFRALDH1A1HPGDTSHRTNKS | |
| SCHEMBL4699926 | 0.73 | DHFR (0.40) | DHFRALDH1A1HPGDTSHRTNKS | |
| SCHEMBL5612502 | 0.73 | DHFR (0.53) | DHFRALDH1A1HPGDTSHRPTGS2 | |
| SCHEMBL4704624 | 0.72 | TDP2 (0.48) | DHFRALDH1A1HPGDTSHRPTGS2 | |
| SCHEMBL4699312 | 0.71 | TDP2 (0.46) | DHFRALDH1A1HPGDTSHRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999132-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM, LLC (BM) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007120454-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM LLC (BM) | 2007-10-25 | — | — | WO | disclosed |