Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 4/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.34 |
| ▸ | PARP1 | P09874 | 4/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699926 | 0.85 | DHFR (0.40) | DHFRTSHRALDH1A1HPGDTNKS | |
| SCHEMBL4158635 | 0.78 | XDH (0.38) | MAPTCSNK2A1XDHTP53 | |
| SCHEMBL4163363 | 0.76 | MAPT (0.53) | TSHRALDH1A1HPGDMAPTLMNA | |
| SCHEMBL4701714 | 0.74 | GRM1 (0.40) | DHFRTSHRALDH1A1HPGDTNKS | |
| SCHEMBL4701748 | 0.72 | DHFR (0.38) | DHFRTSHRALDH1A1HPGDTNKS | |
| SCHEMBL4705425 | 0.72 | TNKS (0.32) | TNKSTNKS2PARP1 | |
| SCHEMBL5611734 | 0.71 | DHFR (0.55) | DHFRTSHRALDH1A1HPGDTNKS | |
| SCHEMBL5611826 | 0.71 | DHFR (0.49) | DHFRTSHRALDH1A1HPGDTNKS | |
| SCHEMBL4699473 | 0.70 | TDP2 (0.45) | DHFRTSHRALDH1A1HPGDTNKS | |
| SCHEMBL5611470 | 0.69 | DHFR (0.55) | DHFRTSHRALDH1A1HPGDTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999132-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM, LLC (BM) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007120454-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM LLC (BM) | 2007-10-25 | — | — | WO | disclosed |