Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.40 |
| ▸ | TACR1 | P25103 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705277 | 0.92 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL4706291 | 0.91 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL4702177 | 0.91 | REN (0.41) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL4704752 | 0.91 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL4704998 | 0.88 | KDM4E (0.37) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL4704429 | 0.88 | CNR2 (0.37) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL4705237 | 0.85 | TACR1 (0.39) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL4705287 | 0.85 | TP53 (0.38) | SLC6A2SLC6A4SLC6A3TACR1CNR2 | |
| SCHEMBL4703140 | 0.83 | REN (0.43) | SLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL3979779 | 0.80 | RXRA (0.41) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |