Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 10/20 | 0.41 |
| ▸ | CTSS | P25774 | 10/20 | 0.41 |
| ▸ | CTSB | P07858 | 9/20 | 0.41 |
| ▸ | CTSK | P43235 | 8/20 | 0.41 |
| ▸ | MAP2 | P11137 | 2/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703250 | 0.89 | CTSL (0.46) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4703327 | 0.89 | CTSL (0.46) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4699905 | 0.80 | CTSS (0.41) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4701807 | 0.79 | TGFBR1 (0.36) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4703971 | 0.78 | CTSS (0.37) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4703631 | 0.78 | CTSL (0.39) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4702148 | 0.78 | CTSS (0.40) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4698971 | 0.78 | CTSL (0.49) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4701723 | 0.77 | KDM4E (0.35) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4703010 | 0.77 | CTSS (0.37) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |