Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 5/20 | 0.39 |
| ▸ | CTSB | P07858 | 5/20 | 0.39 |
| ▸ | CTSS | P25774 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 6/20 | 0.34 |
| ▸ | CHUK | O15111 | 6/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | F13A1 | P00488 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703250 | 0.87 | CTSL (0.46) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4703327 | 0.87 | CTSL (0.46) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4701995 | 0.85 | CTSK (0.37) | CTSLCTSBCTSSCTSKCA2 | |
| SCHEMBL4702728 | 0.82 | RORC (0.35) | CTSLCTSBCTSSCTSKMAPT | |
| SCHEMBL4701632 | 0.81 | FNTA (0.34) | — | |
| SCHEMBL4699525 | 0.80 | CTSL (0.38) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4703027 | 0.80 | CTSK (0.31) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4701807 | 0.79 | TGFBR1 (0.36) | CTSLCTSBCTSSALDH1A1CTSK | |
| SCHEMBL4703330 | 0.78 | CTSL (0.41) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4701723 | 0.77 | KDM4E (0.35) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |