Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706925 | 0.82 | NR1H2 (0.53) | MEN1KMT2AALOX15ALDH1A1SMN1; SMN2 | |
| SCHEMBL21987994 | 0.76 | DPP4 (0.49) | TSHRALDH1A1SMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL4706451 | 0.75 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL4702591 | 0.73 | ALDH1A1 (0.49) | MEN1KMT2APOLBL3MBTL1TSHR | |
| SCHEMBL3450531 | 0.73 | OPRM1 (0.30) | — | |
| SCHEMBL3450527 | 0.72 | F10 (0.45) | — | |
| SCHEMBL6268637 | 0.72 | POLB (0.48) | MEN1KMT2APOLBL3MBTL1TSHR | |
| SCHEMBL4704282 | 0.69 | CHRM1 (0.44) | POLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL30300621 | 0.68 | L3MBTL1 (0.54) | MEN1KMT2APOLBL3MBTL1TSHR | |
| SCHEMBL3738889 | 0.68 | CTSD (0.40) | POLBL3MBTL1TSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-B1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |