Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | CCR9 | P51686 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708326 | 0.81 | MTNR1A (0.43) | MTNR1AMTNR1BKDM4E | |
| SCHEMBL5622754 | 0.80 | MTNR1A (0.61) | MTNR1AMTNR1BDYRK1AMAOACLK1 | |
| SCHEMBL14206927 | 0.76 | DYRK1A (0.51) | MTNR1AMTNR1BDYRK1AMAOACLK1 | |
| SCHEMBL4706772 | 0.76 | MEN1 (0.39) | CCR9MAPTSMN1; SMN2RXFP1KDM4E | |
| SCHEMBL4705661 | 0.75 | KDM4E (0.44) | MTNR1AMTNR1BCCR2MAPTKDM4E | |
| SCHEMBL2242465 | 0.75 | MTNR1A (0.52) | MTNR1AMTNR1BDYRK1AMAOACCR9 | |
| SCHEMBL4707304 | 0.69 | CNR2 (0.42) | CCR2MAPTSMN1; SMN2RXFP1KDM4E | |
| SCHEMBL3817923 | 0.68 | KDM4E (0.60) | CCR9CCR2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4705478 | 0.67 | KDM4E (0.36) | CCR9MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL16246760 | 0.65 | CA2 (0.51) | MTNR1AMTNR1BCCR9CCR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625129-B1 | HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT | BAYER HEALTHCARE AG (DE) | 2008-03-05 | — | — | EP | disclosed |