Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708187 | 0.94 | CYP3A4 (0.44) | KDM4EHRH1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4709041 | 0.90 | PTGS2 (0.40) | KDM4EPTGS2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4780556 | 0.89 | KDM4E (0.46) | KDM4EHRH1CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL4516965 | 0.85 | KDM4E (0.44) | KDM4EHRH1CYP3A4CYP2C19PTGS2 | |
| SCHEMBL4709394 | 0.84 | PTGS2 (0.43) | PTGS2MAPTHTTSMN1; SMN2GRIN2B | |
| SCHEMBL4779231 | 0.82 | CNR2 (0.46) | KDM4EHRH1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4706868 | 0.81 | CYP2A13 (0.43) | KDM4ECYP2A13ALDH1A1NPC1RAB9A | |
| SCHEMBL4774098 | 0.81 | PTGDR2 (0.41) | PTGS2MAPTSMN1; SMN2EGFRTYMS | |
| SCHEMBL4780894 | 0.80 | LMNA (0.47) | KDM4EHRH1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4780919 | 0.80 | CYP2A13 (0.46) | KDM4ECYP3A4CYP2C19CYP2A13ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1873150-A1 | Fluorinated indoleamides useful as ligands of the ORL-1 receptor | NIKEM RESEARCH S.R.L. (IT) | 2008-01-02 | — | — | EP | claimed |
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | disclosed |
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | disclosed |
| EP-1873150-A1 | Fluorinated indoleamides useful as ligands of the ORL-1 receptor | NIKEM RESEARCH S.R.L. (IT) | 2008-01-02 | — | — | EP | disclosed |