Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12989025 | 0.81 | ACHE (0.38) | GPR119HRH3RORC | |
| SCHEMBL470548 | 0.78 | HRH3 (0.38) | GPR119HRH3RORC | |
| SCHEMBL470675 | 0.78 | GPR119 (0.48) | GPR119 | |
| SCHEMBL459455 | 0.75 | GPR119 (0.33) | GPR119HRH3 | |
| SCHEMBL9925927 | 0.74 | MAPT (0.47) | GPR119 | |
| SCHEMBL470679 | 0.74 | GPR119 (0.52) | GPR119 | |
| SCHEMBL384927 | 0.74 | HCRTR2 (0.41) | GPR119 | |
| SCHEMBL11919298 | 0.73 | CKS1B (0.49) | GPR119HRH3 | |
| SCHEMBL8513708 | 0.73 | SMO (0.42) | GPR119 | |
| SCHEMBL24126682 | 0.71 | HRH3 (0.37) | GPR119HRH3RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |