Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779433 | 0.96 | PTGDR2 (0.50) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4778231 | 0.88 | KDM4E (0.46) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4707699 | 0.87 | KDM4E (0.43) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4776203 | 0.86 | KDM4E (0.46) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4778810 | 0.86 | KDM4E (0.46) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4774108 | 0.86 | KDM4E (0.44) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4708162 | 0.86 | CYP2A13 (0.41) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4708788 | 0.85 | KDM4E (0.44) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4780894 | 0.84 | LMNA (0.47) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 | |
| SCHEMBL4773925 | 0.84 | POLB (0.42) | PTGDR2KDM4EPOLBTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | disclosed |
| EP-1873150-A1 | Fluorinated indoleamides useful as ligands of the ORL-1 receptor | NIKEM RESEARCH S.R.L. (IT) | 2008-01-02 | — | — | EP | disclosed |