Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | FABP6 | P51161 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 7/20 | 0.36 |
| ▸ | HTR2C | P28335 | 7/20 | 0.36 |
| ▸ | HTR2B | P41595 | 6/20 | 0.36 |
| ▸ | HTR1A | P08908 | 5/20 | 0.36 |
| ▸ | HTR1D | P28221 | 4/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1143507 | 0.76 | HTR2C (0.45) | DYRK1ADYRK1BHTR2AHTR2CHTR2B | |
| SCHEMBL12463566 | 0.75 | ACHE (0.50) | FABP6PARP10PARP11PARP1ACHE | |
| SCHEMBL4709030 | 0.71 | CDK5 (0.37) | DYRK1ACDK5CLK4DYRK1BPIM1 | |
| SCHEMBL4708565 | 0.69 | KDM4E (0.39) | FABP6HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL9626819 | 0.68 | PKM (0.39) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL4708668 | 0.67 | CDK5 (0.34) | DYRK1ACDK5CLK4DYRK1BPIM1 | |
| SCHEMBL4712134 | 0.67 | CYP1A2 (0.40) | DYRK1ACDK5CLK4DYRK1BPIM1 | |
| SCHEMBL25134030 | 0.65 | ROCK1 (0.47) | DYRK1ACDK5CLK4DYRK1BPIM1 | |
| SCHEMBL14993793 | 0.65 | HTR2C (0.36) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL9628449 | 0.64 | HTR2A (0.41) | HTR2AHTR2CHTR2BHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893617-A1 | TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138549-A1 | TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS | WYETH (US) | 2006-12-28 | — | — | WO | claimed |