Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | STS | P08842 | 15/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31331899 | 0.97 | MAOA (0.67) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL21587877 | 0.81 | KDM4E (0.69) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL30465069 | 0.80 | KDM4E (1.00) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL7532636 | 0.80 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL3768560 | 0.80 | KDM4E (1.00) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL9725288 | 0.80 | KDM4E (0.67) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL3762769 | 0.79 | CYP1A2 (1.00) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL3625077 | 0.79 | CYP1A2 (1.00) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL3757463 | 0.77 | MAOA (1.00) | ALDH1A1HPGDHSD17B10KDM4ETSHR | |
| SCHEMBL7562741 | 0.75 | KDM4E (0.60) | ALDH1A1HPGDHSD17B10KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | claimed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | claimed |
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |