Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711078 | 0.74 | L3MBTL1 (0.42) | — | |
| SCHEMBL3315852 | 0.68 | TEAD1 (0.44) | PDE2AGPR139GRIN2BACACBTEAD1 | |
| SCHEMBL1968535 | 0.66 | HTR2A (0.55) | GRIN2BKCNH2 | |
| SCHEMBL3022629 | 0.64 | ALDH1A1 (0.43) | GPR139GRIN2B | |
| SCHEMBL4713293 | 0.63 | TAAR1 (0.49) | — | |
| SCHEMBL7731888 | 0.63 | ACACB (0.55) | PDE2AACACB | |
| SCHEMBL13683329 | 0.63 | ACACB (0.55) | PDE2AACACB | |
| SCHEMBL31036977 | 0.62 | PDE2A (0.51) | PDE2AGPR139ACACB | |
| SCHEMBL23122208 | 0.61 | HTT (0.57) | PDE2AGPR139 | |
| SCHEMBL23122205 | 0.61 | HTT (0.57) | PDE2AGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |