Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711078 | 0.86 | L3MBTL1 (0.42) | TAAR1L3MBTL1HTR2AAGTR2MBTPS1 | |
| SCHEMBL4714391 | 0.84 | SMN1; SMN2 (0.44) | SLC6A2SLC6A4L3MBTL1 | |
| SCHEMBL27817763 | 0.78 | TAAR1 (0.62) | TAAR1AOC3SLC6A2SLC6A4HTR2A | |
| SCHEMBL22462903 | 0.76 | KCNH2 (0.41) | TAAR1 | |
| SCHEMBL4695317 | 0.73 | KCNH2 (0.53) | CCR5HTR2A | |
| SCHEMBL4715365 | 0.73 | AGTR2 (0.47) | TAAR1AOC3L3MBTL1AGTR2SIGMAR1 | |
| SCHEMBL144125 | 0.73 | KMT2A (0.51) | AGTR2SIGMAR1 | |
| SCHEMBL18422574 | 0.72 | TAAR1 (0.62) | TAAR1AOC3SLC6A2SLC6A4 | |
| SCHEMBL17274372 | 0.71 | NAAA (0.63) | TAAR1CCR5 | |
| SCHEMBL18567998 | 0.71 | MBTPS1 (0.51) | TAAR1AOC3SLC6A2SLC6A4MBTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |