Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713293 | 0.86 | TAAR1 (0.49) | L3MBTL1HTR2AAGTR2MBTPS1TAAR1 | |
| SCHEMBL1968535 | 0.79 | HTR2A (0.55) | HTR2AKDM4EMBTPS1TAAR1 | |
| SCHEMBL4714391 | 0.76 | SMN1; SMN2 (0.44) | L3MBTL1KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL4716650 | 0.75 | TP53 (0.42) | KDM4ELMNAPOLBMAPTKMT2A | |
| SCHEMBL4715365 | 0.75 | AGTR2 (0.47) | L3MBTL1AGTR2TAAR1 | |
| SCHEMBL144125 | 0.75 | KMT2A (0.51) | AGTR2KMT2A | |
| SCHEMBL29056938 | 0.75 | L3MBTL1 (0.66) | L3MBTL1AGTR2POLBKMT2AALDH1A1 | |
| SCHEMBL4710684 | 0.74 | PDE2A (0.41) | — | |
| SCHEMBL28550033 | 0.72 | HRH3 (0.35) | L3MBTL1MAPT | |
| SCHEMBL27544931 | 0.70 | CHIA (0.52) | L3MBTL1AGTR2POLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |