Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GFER | P55789 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577171 | 0.89 | MAPT (0.47) | MAPTALDH1A1KMT2AKDM4EGFER | |
| SCHEMBL29348778 | 0.85 | DRD2 (0.53) | ALDH1A1KMT2AGAAMEN1NPC1 | |
| SCHEMBL25685276 | 0.84 | MGLL (0.43) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL29348779 | 0.84 | MEN1 (0.38) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6362778 | 0.83 | MEN1 (0.61) | KMT2AKDM4EDDB1CRBNMEN1 | |
| SCHEMBL20057689 | 0.81 | DRD2 (0.36) | MAPTALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL20313983 | 0.81 | GAA (0.49) | MAPTALDH1A1KMT2AKDM4EGFER | |
| SCHEMBL2555563 | 0.80 | HRH3 (0.37) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL21594874 | 0.80 | RAB9A (0.42) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL21594891 | 0.80 | CHKA (0.50) | ALDH1A1KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824844-B1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1824844-B1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1824844-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2007-08-29 | — | — | EP | disclosed |
| US-20070135442-A1 | Chroman compounds | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| US-20070135442-A1 | Chroman compounds | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| US-20070135442-A1 | Chroman compounds | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| WO-2007053094-A1 | CHROMAN COMPOUNDS AS 5 -HTlB ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007053094-A1 | CHROMAN COMPOUNDS AS 5 -HTlB ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| US-20060287315-A1 | Pyrazinedicarboxamides and their use | BAYER HEALTHCARE AG (DE) | 2006-12-21 | — | — | US | disclosed |
| WO-2006061116-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-15 | — | — | WO | disclosed |
| WO-2006061116-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287315-A1 | Pyrazinedicarboxamides and their use | PEPD, AADAC, PYCARD | MAPT 4489/4885ALDH1A1 2019/4885KMT2A 1950/4885 |
| US-20070135442-A1 | Chroman compounds | CYP3A43, CYP2C9, CYP2C8 | MAPT 3096/4885ALDH1A1 1546/4885KMT2A 2880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.