Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711602 | 0.86 | LMNA (0.57) | SMN1; SMN2ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL25232330 | 0.84 | SMN1; SMN2 (0.77) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL2940862 | 0.84 | SMN1; SMN2 (0.77) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL13378300 | 0.81 | SMN1; SMN2 (0.72) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL4440443 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL16517803 | 0.81 | SMN1; SMN2 (0.75) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL2232200 | 0.81 | CA1 (0.58) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL128190 | 0.80 | CA1 (0.70) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL725878 | 0.80 | ALDH1A1 (0.72) | ALDH1A1NPC1CYP1A2CYP2D6LMNA | |
| SCHEMBL11988605 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402595-B2 | Enzyme inhibitors with isoquinolinone structures | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-22 | — | — | US | disclosed |
| US-20050148624-A1 | Jnk inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148624-A1 | Jnk inhibitor | MAPK3, MAPKAPK3, MAPK1 | SMN1; SMN2 4193/4885HTT 3943/4885ALDH1A1 4549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.