Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 6/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxilofrine SCHEMBL147458 | 0.81 | ADRA1A (0.67) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| SCHEMBL20690347 | 0.81 | HIF1A (0.56) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| SCHEMBL28340700 | 0.81 | ADRA2C (0.67) | ADRA1AHIF1ACYP2D6LMNASLC6A4 | |
| Oxilofrine SCHEMBL4256893 | 0.81 | ADRA1A (0.67) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| Oxilofrine SCHEMBL14153976 | 0.81 | ADRA1A (0.67) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| Oxilofrine SCHEMBL5173040 | 0.81 | ADRA1A (0.67) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| Oxilofrine SCHEMBL14465574 | 0.81 | ADRA1A (0.67) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| SCHEMBL27623223 | 0.80 | HIF1A (0.53) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| SCHEMBL2123890 | 0.79 | HIF1A (0.54) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 | |
| SCHEMBL16144662 | 0.79 | HIF1A (0.55) | ADRA1AHIF1ASLC6A2OPRM1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1887007-A2 | Novel compounds | AstraZeneca AB (SE) | 2008-02-13 | — | — | EP | claimed |
| EP-1625126-B1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | claimed |
| US-20060287355-A1 | Imidazo and thiazolopyridines as jak3 kinase inhibitors | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | US | claimed |
| EP-1887007-A2 | Novel compounds | AstraZeneca AB (SE) | 2008-02-13 | — | — | EP | disclosed |
| EP-1625126-B1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | disclosed |
| US-20060287355-A1 | Imidazo and thiazolopyridines as jak3 kinase inhibitors | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287355-A1 | Imidazo and thiazolopyridines as jak3 kinase inhibitors | JAK3, JAK2, JAK1 | ADRA1A 2780/4885HIF1A 2395/4885SLC6A2 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.