Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2679794 | 0.82 | LMNA (0.61) | GAAKDM4ELMNASMN1; SMN2NPSR1 | |
| SCHEMBL7449220 | 0.80 | SMN1; SMN2 (0.68) | LMNASMN1; SMN2ALDH1A1MAPTCYP2D6 | |
| SCHEMBL7581128 | 0.80 | POLB (0.74) | KDM4ELMNAHTTSMN1; SMN2HPGD | |
| SCHEMBL28037841 | 0.80 | EPHX2 (0.72) | LMNASMN1; SMN2HPGDALDH1A1CYP2D6 | |
| SCHEMBL3955220 | 0.79 | SMN1; SMN2 (0.71) | GAAKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL1744820 | 0.78 | LMNA (0.56) | LMNASMN1; SMN2ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL17478759 | 0.77 | LMNA (0.64) | GAALMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL14301340 | 0.77 | L3MBTL1 (0.65) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL17478623 | 0.76 | KDM4E (0.66) | GAAKDM4ELMNAALDH1A1MAPT | |
| SCHEMBL20363501 | 0.76 | CES2 (0.65) | GAALMNAHTTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891066-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006124462-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2006-11-23 | — | — | WO | disclosed |