Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10756135 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL29975243 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL6889978 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL31148323 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL5681342 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL844236 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL4146683 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL6557896 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL7784647 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL4438369 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872300-A | Process for the preparation of 2-amino-6-chlorophenyl-alkylsulfanes, and 2-amino-6-chlorophenyl-isopropylsulfane | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-16 | — | — | US | claimed |
| EP-0775693-A1 | Process for the preparation of 2-amino-6-chlorophenyl-alkylsulfides and 2-amino-6-chlorophenyl-isopropylsulfide | BAYER AG (DE) | 1997-05-28 | — | — | EP | claimed |
| EP-1877401-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | Elan Pharmaceuticals Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | ELAN PHARMACEUTICALS, INC. | 2007-02-08 | — | — | US | disclosed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| EP-0976725-B1 | Process for the continuous preparation of amino-halogenophenyl alkyl thioethers | BAYER CHEMICALS AG (DE) | 2004-03-03 | — | — | EP | disclosed |
| JP-2000053636-A | CONTINUOUS PRODUCTION OF AMINO-HALOGENOPHENYL ALKYL THIOETHER | BAYER AG | 2000-02-22 | — | — | JP | disclosed |
| EP-0711754-B1 | Process for preparing 2-chloro-6-nitrophenylalkylsulfides as well as novel 2-chloro-6-nitrophenyl alkylsulfides | BAYER AG (DE) | 1999-03-10 | — | — | EP | disclosed |
| US-5872300-A | Process for the preparation of 2-amino-6-chlorophenyl-alkylsulfanes, and 2-amino-6-chlorophenyl-isopropylsulfane | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-16 | — | — | US | disclosed |
| EP-0775693-A1 | Process for the preparation of 2-amino-6-chlorophenyl-alkylsulfides and 2-amino-6-chlorophenyl-isopropylsulfide | BAYER AG (DE) | 1997-05-28 | — | — | EP | disclosed |
| EP-0711754-A1 | Process for preparing 2-chloro-6-nitrophenylalkylsulfides as well as novel 2-chloro-6-nitrophenyl alkylsulfides | BAYER AG (DE) | 1996-05-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | BDKRB1, BDKRB2, NPBWR1 | ALDH1A1 3073/4885KDM4E 4606/4885MAPT 3303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.