SCHEMBL4717563

SCHEMBL4717563

O=C(Cl)CCc1c(F)cccc1F

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.42
ALDH1A1 P00352 1/20 0.42
ALOX15 P16050 1/20 0.42
CES2 O00748 2/20 0.41
CES1 P23141 2/20 0.41
KDM4E B2RXH2 2/20 0.41
FFAR1 O14842 1/20 0.41
FFAR4 Q5NUL3 1/20 0.41
GAA P10253 1/20 0.40
ALB P02768 1/20 0.39
MAPT P10636 2/20 0.39
KMT2A Q03164 1/20 0.39
DAO P14920 1/20 0.39
MPO P05164 3/20 0.38
CNR1 P21554 1/20 0.38
BCHE P06276 1/20 0.38
TP53 P04637 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2031884 0.84 STIM1 (0.41) TAAR1ALDH1A1GAA
SCHEMBL27558917 0.83 CES2 (0.44) TAAR1ALDH1A1CES2CES1KDM4E
SCHEMBL4718220 0.82 CES2 (0.38) ALDH1A1ALOX15CES2CES1KDM4E
SCHEMBL19438660 0.81 MPO (0.54) TAAR1ALDH1A1CES2CES1KDM4E
SCHEMBL4714927 0.81 FFAR1 (0.59) ALDH1A1CES2CES1KDM4EFFAR1
SCHEMBL4714251 0.79 CNR1 (0.43) TAAR1ALDH1A1CES2CES1FFAR1
SCHEMBL6158818 0.79 ALDH1A1 (0.50) TAAR1ALDH1A1CES2CES1KDM4E
SCHEMBL4322411 0.79 CES2 (0.42) TAAR1ALDH1A1ALOX15CES2CES1
SCHEMBL3949072 0.78 MAPT (0.45) TAAR1ALDH1A1ALOX15CES2CES1
SCHEMBL30799043 0.78 TAAR1 (0.52) TAAR1ALDH1A1ALOX15FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1337517-B1 PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 2008-11-26 EP disclosed
EP-1337517-A1 PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 2003-08-27 EP disclosed
WO-2002030911-A1 PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM P.L.C. (GB) 2002-04-18 WO disclosed