Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406557 | 0.82 | NR3C1 (0.43) | HSD11B1 | |
| SCHEMBL4717851 | 0.77 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL4718198 | 0.77 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL13294073 | 0.76 | HSD11B1 (0.62) | HSD11B1 | |
| SCHEMBL4717585 | 0.75 | IRAK4 (0.42) | — | |
| SCHEMBL13294035 | 0.74 | HSD11B1 (0.60) | HSD11B1 | |
| SCHEMBL13294030 | 0.74 | HSD11B1 (0.59) | HSD11B1 | |
| SCHEMBL13294039 | 0.73 | HSD11B1 (0.58) | HSD11B1 | |
| SCHEMBL1406946 | 0.73 | KEAP1 (0.40) | HSD11B1 | |
| SCHEMBL4718010 | 0.71 | PDE4B (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |