Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 4/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.44 |
| ▸ | CENPE | Q02224 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718072 | 0.89 | CENPE (0.46) | MEN1KMT2ACENPEKDM4ECYP1A2 | |
| SCHEMBL4720150 | 0.88 | PTGES (0.46) | KMT2ACENPENPC1RAB9AHPGD | |
| SCHEMBL2104713 | 0.87 | CENPE (0.48) | MEN1KMT2ATRPM8RAF1MAP2K1 | |
| SCHEMBL4721152 | 0.84 | CENPE (0.52) | MEN1KMT2ACENPESMN1; SMN2CYP1A2 | |
| SCHEMBL4722528 | 0.81 | CENPE (0.53) | MEN1KMT2ACENPENPC1RAB9A | |
| SCHEMBL4720776 | 0.80 | CENPE (0.44) | MEN1KMT2ACENPEHPGDKDM4E | |
| SCHEMBL4720907 | 0.80 | TRPM8 (0.50) | MEN1KMT2ATRPM8RAF1MAP2K1 | |
| SCHEMBL13584065 | 0.79 | MEN1 (0.51) | MEN1KMT2ATRPM8RAF1MAP2K1 | |
| SCHEMBL4721237 | 0.79 | SPHK2 (0.44) | KMT2ACENPEKDM4ECYP1A2CYP2C9 | |
| SCHEMBL13711251 | 0.77 | MEN1 (0.47) | MEN1KMT2ATRPM8RAF1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |