Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721152 | 0.88 | CENPE (0.52) | CENPECSNK2A1RORCMEN1KMT2A | |
| SCHEMBL4722528 | 0.85 | CENPE (0.53) | CENPERORCMEN1KMT2ALMNA | |
| SCHEMBL4718072 | 0.84 | CENPE (0.46) | CENPEMEN1KMT2ATSHRKDM4E | |
| SCHEMBL2104606 | 0.84 | CENPE (0.48) | CENPECSNK2A1RORCMEN1KMT2A | |
| SCHEMBL4720908 | 0.80 | MEN1 (0.47) | CENPEMEN1KMT2AKDM4EBLM | |
| SCHEMBL4720150 | 0.80 | PTGES (0.46) | CENPEKMT2ATSHRMAPTP2RX3 | |
| SCHEMBL4521076 | 0.80 | CENPE (0.47) | CENPECSNK2A1RORCMEN1KMT2A | |
| SCHEMBL4719991 | 0.77 | CENPE (0.48) | CENPECSNK2A1RORCMEN1KMT2A | |
| SCHEMBL4717871 | 0.77 | CENPE (0.43) | CENPE | |
| SCHEMBL4720774 | 0.75 | CENPE (0.47) | CENPECSNK2A1RORCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |