Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521076 | 0.91 | CENPE (0.47) | CENPES1PR1S1PR3KIFC1MEN1 | |
| SCHEMBL4719991 | 0.89 | CENPE (0.48) | CENPES1PR1S1PR3KIFC1MEN1 | |
| SCHEMBL4722528 | 0.89 | CENPE (0.53) | CENPEMEN1KMT2AP2RX3RORC | |
| SCHEMBL4720776 | 0.88 | CENPE (0.44) | CENPES1PR1S1PR3KIFC1MEN1 | |
| SCHEMBL4718072 | 0.88 | CENPE (0.46) | CENPEMEN1KMT2AP2RX3CYP1A2 | |
| SCHEMBL2103268 | 0.85 | CENPE (0.56) | CENPES1PR1S1PR3KIFC1MEN1 | |
| SCHEMBL4717871 | 0.84 | CENPE (0.43) | CENPE | |
| SCHEMBL4720908 | 0.84 | MEN1 (0.47) | CENPEMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL4720150 | 0.84 | PTGES (0.46) | CENPEKMT2AP2RX3MAPTSMN1; SMN2 | |
| SCHEMBL2104964 | 0.82 | CENPE (0.53) | CENPES1PR1S1PR3KIFC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |