Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCND3 | P30281 | 4/20 | 0.35 |
| ▸ | CDK7 | P50613 | 4/20 | 0.35 |
| ▸ | CDK9 | P50750 | 4/20 | 0.35 |
| ▸ | CCNH | P51946 | 4/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721855 | 0.91 | GPR119 (0.41) | GPR119TBK1IKBKEGPR6CCNT1 | |
| SCHEMBL4719081 | 0.91 | GPR119 (0.48) | GPR119CCNT1CCNA2CDK2CCND3 | |
| SCHEMBL4723713 | 0.89 | GPR119 (0.53) | GPR119CCNT1CCNA2CDK2CCND3 | |
| SCHEMBL390031 | 0.88 | GPR119 (0.54) | GPR119TBK1IKBKE | |
| SCHEMBL4721156 | 0.88 | GPR119 (0.46) | GPR119CCNT1CCNA2CDK2CCND3 | |
| SCHEMBL4723743 | 0.86 | GPR119 (0.52) | GPR119 | |
| SCHEMBL4718549 | 0.85 | GPR119 (0.46) | GPR119GPR6CCNT1CCNA2CDK2 | |
| SCHEMBL4721934 | 0.83 | GPR119 (0.51) | GPR119CDK2CDK6 | |
| SCHEMBL4724482 | 0.82 | GPR119 (0.38) | GPR119TBK1IKBKECCNT1CCNA2 | |
| SCHEMBL4719030 | 0.81 | GPR119 (0.67) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |