Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.47 |
| ▸ | CCR3 | P51677 | 20/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14110514 | 0.87 | HRH1 (0.61) | HRH1CCR3KCNH2 | |
| SCHEMBL2196095 | 0.83 | OPRK1 (0.39) | HRH1CCR3KCNH2 | |
| SCHEMBL8530303 | 0.83 | LPL (0.47) | KCNH2 | |
| SCHEMBL8536867 | 0.82 | CCR5 (0.40) | — | |
| SCHEMBL28053867 | 0.81 | OPRK1 (0.41) | KCNH2 | |
| SCHEMBL4101596 | 0.79 | GPR119 (0.53) | KCNH2 | |
| SCHEMBL5109347 | 0.79 | HRH1 (0.61) | HRH1CCR3KCNH2 | |
| SCHEMBL4111964 | 0.78 | APP (0.42) | — | |
| SCHEMBL4632460 | 0.78 | MAPT (0.36) | — | |
| SCHEMBL14237503 | 0.77 | KCNH2 (0.36) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1493743-B1 | Substituted bipiperidine intermediates and derivatives thereof | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | EP | disclosed |