⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719477 | 0.79 | KMT2A (0.33) | — | |
| SCHEMBL4719612 | 0.70 | LMNA (0.36) | — | |
| SCHEMBL7434355 | 0.69 | — | — | |
| SCHEMBL10943194 | 0.67 | CA2 (0.33) | — | |
| SCHEMBL11874913 | 0.67 | HDAC4 (0.39) | — | |
| SCHEMBL8048744 | 0.62 | MPO (0.31) | — | |
| SCHEMBL10951106 | 0.62 | LMNA (0.34) | — | |
| SCHEMBL10895319 | 0.62 | — | — | |
| SCHEMBL8569735 | 0.61 | KDM4E (0.30) | — | |
| SCHEMBL10986583 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839192-B1 | AN IMPROVED IMMOBILIZED PENICILLIN G ACYLASE | DSM IP ASSETS BV (NL) | 2008-12-10 | — | — | EP | disclosed |
| EP-1416054-B1 | Simple enzymatic process for preparing cefazolin | BIOFERMA MURCIA S A (ES) | 2005-08-17 | — | — | EP | disclosed |
| EP-1556500-A1 | SIMPLE ENZYMATIC PROCESS FOR PREPARING CEFAZOLIN | Bioferma Murcia, S.A. (ES) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004039997-A1 | SIMPLE ENZYMATIC PROCESS FOR PREPARING CEFAZOLIN | BIOFERMA MURCIA, S.A. (ES) | 2004-05-13 | — | — | WO | disclosed |
| EP-1416054-A1 | Simple enzymatic process for preparing cefazolin | Bioferma Murcia, S.A. (ES) | 2004-05-06 | — | — | EP | disclosed |
| US-6060268-A | PROVIDES A HIGHER SYNTHESIS/HYDROLYSIS RATIO; FOR PRODUCTION OF BETA-LACTAM DERIVATIVES SUCH AS CEPHALOSPORINS AND PENICILLINS BY REACTING AN AMINO BETA-LACTAM WITH AN ACYLATING AGENT IN THE PRESENCE OF THE IMMOBILIZED ENZYME | GIST-BROCADES B.V. (NL) | 2000-05-09 | — | — | US | disclosed |
| EP-0839192-A1 | AN IMPROVED IMMOBILIZED PENICILLIN G ACYLASE | GIST-BROCADES B.V. (NL) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997004086-A1 | AN IMPROVED IMMOBILIZED PENICILLIN G ACYLASE | GIST-BROCADES B.V. (NL) | 1997-02-06 | — | — | WO | disclosed |